Endocrine Abstracts

Introduction: Secondary hormonal deficiencies (SHD) are frequently observed in patients with pituitary adenomas. We previously reported that pituitary tumour clinical subtypes were associated with specific patterns of SHD, and nonfunctioning adenomas (NFAs) were more likely to present with multiple SHD. We extended our work to examine if the immunohistochemical staining patterns of NFAs impacted SHD.Methods: All clinically NFAs surgically removed between...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...

The guidelines for management of prolactinomas (PRLoma) during pregnancy are mostly based on retrospective evidence or expert opinion. We conducted a survey of four Canadian provinces (NS, NB, PEI and BC) to assess the current trends in management of PRLoma during pregnancy. A case-based electronic questionnaire was sent to all practicing endocrinologists, with 3 cases of varying severity ranging from a micro PRLoma to a large macroPRLoma compressing the optic chiasm. A total ...

Introduction: Pituitary apoplexy is a rare clinical syndrome that often involves headache, visual deficits, and endocrine dysfunction resulting from infarction or hemorrhage of a pituitary tumor. Due in part to the rare nature of this condition, there are few large studies on pituitary apoplexy described in the literature. Here, we present a large single center retrospective cohort study of patients with pituitary apoplexy managed surgically or conservatively.<p class="abs...

Introduction: While there is a significant risk of recurrence in nonfunctioning pituitary adenoma (NFPA) after surgery, it is challenging to predict which NFPAs will recur based solely on routine histopathology. To better understand markers of recurrence, we assessed the established tumor markers linked to aggressive tumor behavior including X-linked IAP (XIAP), the most potent inhibitor of the apoptosis protein family, vascular epithelial growth factor (VEGF) which facilitate...

Patients with acromegaly (PWA) experience higher rates of falls and fall-related injuries than age-matched Canadian adults. Previous studies of standing balance revealed increased sway in PWA compared to healthy controls but failed to control for the effects of the pituitary adenoma. Therefore, the aim of the present study was to determine if acromegaly influenced the neuromuscular control of standing balance. Bipedal standing balance was evaluated in PWA (n=13) in bi...

Acromegaly triggers, and is associated with, peripheral nervous system modifications and joint degenerations, which are considered to impact the walking balance of patients with acromegaly (PWA). Therefore, to better understand if these systemic degenerations impact the transitory adaptations in locomotor patterns of these patients, this study aims to establish the walking balance deficits of PWA. Walking balance was evaluated in PWA (n=8) in biochemical remission and...

Acromegaly, characterized by growth hormone excess, adversely affects the patients’ musculoskeletal and neural systems, consequently impairing physical function. Previous studies have noted walking impairments in patients with acromegaly (PWA). This study aimed to characterize the kinematic and kinetic changes during walking in PWA. Kinematics and kinetics of walking were evaluated in PWA (n=8) in biochemical remission and a control group of patients with non-fun...

Secondary hormonal deficiency (SHD) is common in patients presenting with nonfunctioning pituitary adenomas (NFA). NFA can either stain for various hormones or be non-hormone staining on immunocytochemistry. To date, no study has assessed the association between staining pattern of NFA and pattern of SHD at presentation. The Halifax Neuropituitary Program has been prospectively collecting comprehensive data on all neuropituitary patients in the province of Nova Scotia, Canada ...